Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis

Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis

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Given the growing evidence of a link between gut microbiota (GM) dysbiosis air compressor tank bushing and multiple sclerosis (MS), fecal microbiota transplantation (FMT), aimed at rebuilding GM, has been proposed as a new therapeutic approach to MS treatment.To evaluate the viability of FMT for MS treatment and its impact on MS pathology, we tested FMT in mice with experimental autoimmune encephalomyelitis (EAE), a mouse model of MS.We provide evidence that FMT can rectify altered GM to some extent with a therapeutic effect on EAE.We also found that FMT led to reduced activation of microglia and astrocytes and conferred protection on the plastic molcajete bowls blood-brain barrier (BBB), myelin, and axons in EAE.

Taken together, our data suggest that FMT, as a GM-based therapy, has the potential to be an effective treatment for MS.